Endocrine Abstracts

Aim: The work was initiated to study TNF-α gene polymorphism and parameters of oxidative stress in patients with type 2 diabetes mellitusMaterials and methods: We examined 41 healthy subjects and 20 patients with diabetes mellitus to study G308A (rs1800629) polymorphism in TNF-α gene by means of allele-specific PCR method (AS-PCR). Rates of lipid peroxidation (LP) were determined by concentration of malon dialdehyde (MDA); catalase activity was...

According to the findings from the recent studies, the oxidative stress can be a cause for type 2 diabetes mellitus onset. In that context, the development of drugs with antioxidant effect to be used for prevention and treatment of the disease is of vital importance. The work was initiated to study the oxidative stress in the experimental diabetes and methods of its correction by means of natural antioxidants. In our study we used polyphenols isolated from the seeds of common ...